A new experimental drug, Retatrutide, has been dubbed the 'Godzilla' of weight loss jabs due to its unprecedented efficacy in early trials, but experts are sounding the alarm over its alarming surge in black market demand. Manufactured by Eli Lilly, this once-weekly injection is still in Phase 3 clinical trials, with full results not expected until 2026 or 2027. Unlike existing slimming injections, Retatrutide, also known as 'triple G' because it targets three hormones (GLP, GIP, and glucagon) involved in eating and weight regulation, not only suppresses appetite but also significantly speeds up metabolism. Early studies have shown that participants on the highest dose can shed nearly a quarter of their body weight in under a year, with some women losing an average of 28.5 percent and men 21.2 percent over 48 weeks. This dramatically outperforms other popular drugs like Ozempic (up to 15% weight loss) and Mounjaro (up to 22.5%).

Despite its unapproved status, social media platforms are rife with users claiming to have sourced 'Reta' or 'Ret' on the black market, boasting of rapid weight loss. This illicit trade has been fueled by the drug's promising trial results and a reported 5000 percent spike in UK online searches for 'where to inject Retatrutide' following Eli Lilly's announcement of increased Mounjaro costs. Health experts and authorities are issuing stern warnings against engaging with the black market, stressing the severe health and legal risks involved. Danielle Brightman, clinical director at Numan, highlighted that such unregulated products offer no guarantee about dose, purity, or active ingredients, potentially exposing users to serious side effects, contamination, or long-term harm. She also reminded the public that possessing unlicensed medication like Retatrutide is illegal under UK law, carrying penalties of up to two years in prison and unlimited fines.

Eli Lilly itself has issued a stark warning, stating that Retatrutide is an investigational molecule not available outside clinical trials, and any product falsely representing itself as such may expose patients to serious health risks. Reports indicate that counterfeit versions of the drug, sometimes originating from Chinese firms offering samples for as little as 80p a dose labeled 'research only,' have already been found on sale in Britain. Border officials have intercepted dangerous 'DIY' injection kits, and tests on black-market Mounjaro and Ozempic have even revealed contamination with rat poison and cement. Social media platforms like TikTok have begun banning videos promoting Retatrutide, and doctors are advising patients about the unknown contents of these illicit supplies.

The dangers of obtaining these drugs unofficially are illustrated by personal accounts. Erin, a 29-year-old single mother, turned to black-market Retatrutide after finding semaglutide and Mounjaro ineffective. She sourced the drug from a beautician friend, initially experiencing severe cramps and headaches. While she reported a 6-pound weight loss in a month and reduced cravings, experts caution against such practices, noting that the real Retatrutide's full risks are still being assessed in trials. Rapid weight loss on this scale can lead to its own dangers, including malnutrition, loss of lean muscle, gallstones, and kidney problems – risks also associated with bariatric surgery.

Another example of unofficial use comes from NHS receptionist Siobhan Jackson, 40, who lost four stone by 'microdosing' Mounjaro, splitting her slimming jabs into smaller, more frequent doses against official guidance. Despite her success and belief that the method saved money and offered more control, doctors vehemently warn against it. NHS psychiatrist Dr. Max Pemberton emphasized risks like incorrect dosing, damaging the drug, or a false sense of security. Professor Alex Miras, an endocrinologist, added that pens can malfunction if used improperly and lose sterility once opened, leading to potential life-threatening infections. The Medicines and Healthcare products Regulatory Agency (MHRA) urges patients to strictly follow prescribed dosing directions, warning that failure to adhere to guidelines could harm health or cause personal injury.

While Retatrutide's ability to preserve lean muscle might mitigate some rapid weight loss harms, doctors stress the need for much more data on its safety. Critics also worry that pressure to achieve dramatic results in trials could push doses to dangerous limits. The ongoing concerns surrounding black market accessibility and unofficial dosing practices for powerful weight-loss drugs underscore a critical public health challenge, with experts repeatedly urging individuals to prioritize safety and only obtain medicines from licensed pharmacies with valid prescriptions.