Disclosure: Santiago A. Lozano-Calderón is a consultant for Onkos Inc., IlluminOss Inc., Bone Support, and Johnson & Johnson Inc., and a paid speaker for Carbofix and Amgen. Ian L. Valerio is a consultant for AxoGen Inc, Checkpoint Surgical Inc, and Integra Lifesciences Inc. Kyle R. Eberlin is a consultant for AxoGen Inc, Checkpoint Surgical Inc., Integra Lifesciences Inc., Tissium, Tulavi Therapeutics Inc., and Biocircuit. Floris V. Raasveld, Tareq Hanna, Fernando J. Pacheco, Marcos R. Gonzalez, and Benjamin Johnston have no disclosures to declare that may be relevant to the contents of this study.