SEATTLE — A Yankees offense that totaled 40 runs and 53 hits — including 12 homers — during the first four games of this road trip was due for a drop-off.

That eventuality came Tuesday night.

After the Yankees, stifled over the first eight innings, rallied for a run in the ninth against Mariners closer Andres Munoz — who previously had not allowed an earned run in 18 innings this season — they fell in 11 innings, 2-1, on J.P. Crawford’s walk-off single off Tim Hill in front of 30,840 at T-Mobile Park.

After the Yankees stranded a pair of runners in both the 10th and 11th — failing to get their ghost runner in from third with one out in the 11th when Austin Wells popped out, Anthony Volpe walked and Jasson Dominguez grounded out — Seattle won it in the bottom of the 11th when Crawford, swinging at the first pitch he saw from Hill, slapped a single to left to drive in ghost runner Leody Tavares. Ben Williamson had singled with none out to send Tavares to third.

Deposed closer Devin Williams, who took over in the 10th after Luke Weaver threw two scoreless innings, escaped a runner-on-third, one-out jam in the bottom of the 10th.

The ninth featured the Yankees finally pushing across a run without the benefit of a hit, but also the second ejection of the season for manager Aaron Boone, tossed by plate umpire Mark Wegner after  Dominguez took a called third strike on a pitch that appeared low.

Dominguez  hung around the plate to discuss the call, though not heatedly. As Boone came out to intercept him, he said something that got him immediately thrown out, and the manager then went nose-to-nose with the crew chief.

“I was surprised because it was low,’’ Dominguez said. “It is what it is, but I was shocked.”

“I wasn’t even going out to argue,’’ Boone said. “Obviously it was a bad call, and everyone knew it. You don’t see JD react like that, so I was trying to just go out and make sure JD was staying in the game. I was trying to get my player out of there and I thought it was kind of a quick run there. Clearly he missed one in a big spot there. I kind of yelled [at Wegner], but I was more trying to be a distraction and get JD out of there. I thought it was a little quick.”

It was the first loss by the Yankees this season in a game started by Max Fried, who, though solid over five innings, wasn’t nearly as sharp as he’d been in starting the year 6-0 with a 1.05 ERA (his ERA rose to 1.11). The Yankees (24-18) had been 8-0 in the lefthander’s starts.

Fried allowed one run, four hits and two walks, striking out five. He was outpitched by righthander Bryan Woo, who entered the night 4-1 with a 3.25 ERA. He allowed four hits and struck out six in 6 1⁄3 innings in a crisp 88-pitch outing in which he retired 15 straight at one point.

Boone said it was “a grind” for Fried, who said: “Yeah, definitely. They put together some really good at-bats and drove my pitch count up, especially after a really quick first [five pitches]. Definitely had to make pitches and dig deep and got bailed out by some really good defense . . . They were in it every pitch, just being able to foul off a lot. They were on time and they were definitely ready for what I was throwing. Sometimes that’s the way the game shakes out. Definitely was fighting some command at times, too.”

The Yankees were outhit 6-5 by the Mariners (23-18) and put only two runners in scoring position through eight innings.

Munoz, the American League’s Reliever of the Month for March/April, hit Paul Goldschmidt on the right knuckles with a 98-mph fastball to start the ninth and the first baseman stole second before giving way to pinch runner Pablo Reyes. Wells hit a slow roller to third for the first out, but it got Reyes to third.  Volpe hit a check-swing grounder to first baseman Dylan Moore, who made a wild throw to catcher Cal Raleigh, with Reyes scoring to tie it and Volpe reaching second.

After DJ LeMahieu — making his first appearance of the season — and Trent  Grisham struck out to begin the 10th, the Mariners intentionally walked Aaron Judge to put runners on first and second for Cody Bellinger, who flied out.

Did Bellinger expect Seattle to intentionally walk Judge there? “100%,'' he said. "You’re 100% walking Judge there. I knew I was going to get up there with the guy on first and second, had a good game plan, I just didn’t come through. I have to be a little better there.”

The Mariners got on the board in the fourth. Julio Rodriguez stung a leadoff single to left and Raleigh hammered a 94-mph fastball 401 feet over the head of  Grisham for a 1-0 lead.