Four children aged two years and younger have died in a fire at a house in Mayfair, west of the Johannesburg CBD.

The city's emergency response team said they responded to the incident at about 11am on Monday .

Spokesperson Robert Mulaudzi said: "On arrival, firefighters found the house alight and started conducting firefighting operations. While conducting search and rescue operation, four bodies of young kids were recovered.

"Unfortunately, they were confirmed dead at the scene. It appears they might have suffered smoke inhalation."