Case Reports

Jaypee Brothers Medical Publishing

Indian Journal of Critical Care Medicine

https://doi.org/10.5005/jp-journals-10071-23421

Faridabad

School of Medicine

2020

Parvovirus B19 has rarely been associated with acute liver failure (ALF), which has a high mortality. Plasma exchange that usually acts as a bridge to liver transplantation removes toxins, antibodies, cytokines, and can correct coagulopathy while maintaining a euvolemic state. Pediatric data regarding its use are scarce. We report a case of 16-year-old girl with acute liver failure in stage 4 encephalopathy with coagulopathy due to parvovirus B19 who was successfully managed with high-volume therapeutic plasma exchange (TPE). We tried to use it as a treatment modality due to nonavailability of in-hospital transplant facilities. Parvovirus B19 may be an underdiagnosed cause of acute viral hepatitis. Therapeutic plasma exchange can act as a bridge to liver transplant (LT) or bridge to recovery especially in self-limiting illnesses such as viral hepatitis.

Devki Nandan, Dhirendra P Singh, Sheetal Agarwal, Ruby Singh, Anubhav Gupta, Therapeutic Plasma Exchange in Parvovirus B19-induced Acute Hepatic Failure, Indian Journal of Critical Care Medicine, 24(5):361, Jaypee Brothers Medical Publishing, 2020, https://doi.org/10.5005/jp-journals-10071-23421