The City of Palm Springs confirmed the explosion happened just before 11 a.m. on North Indian Canyon Drive near East Tachevah Drive, and reports said it originated in a vehicle parked outside the American Reproductive Centers.

The explosion heavily damaged the clinic while killing one person and shattering windows at multiple other businesses.

Lt. William Hutchinson with the Palm Springs Police Department told the Palm Springs Post the explosion was caused by a bomb in or near the vehicle.

"Everything is in question, whether this is an act of terrorism," Hutchinson said.

Video from the scene showed damage to buildings and smoke in the area of the reported explosion. Residents also reported online feeling the shaking from the blast throughout the city.

As authorities investigate, North Palm Canyon Drive is closed at Vista Chino. Traffic is being redirected near the north end of the crime scene, which starts at the intersection of North Palm Canyon and Camino Monte Vista.

U.S. Attorney Bill Essayli posted a message on X saying, "We are aware of the explosion that occurred this morning in Palm Springs. FBI is on scene and will be investigating whether this was an intentional act. We will release as much information as possible once we are able to confirm details."

The American Reproductive Centers facility was not open at the time of the blast. According to the business's website, the clinic is the Coachella Valley's "first and only full-service fertility center and IVF (in vitro fertilization) lab." Its services also include LGBTQ family building, egg donation and freezing, fertility evaluations and embryo transfer.

Dr. Maher Abdallah, who runs the clinic, posted a message on social media saying the facility's office space was damaged, but the lab was untouched. He confirmed that no employees of the clinic were injured.

Abdallah said, "A vehicle exploded in the parking lot near our building."

He continued, "We are immensely grateful to share that no members of the ARC team were harmed, and our lab — including all eggs, embryos, and reproductive materials — remains fully secure and undamaged. We are heavily conducting a complete safety inspection and have confirmed that our operations and sensitive medical areas were not impacted by the blast."

Abdallah said the clinic would be open for business on Monday, despite the extensive damage.

Scott Pastorius, a construction project manager from Los Angeles, was in his vacation home four blocks away from the explosion site when he heard a loud boom, he said in an interview with The New York Times.

According to Pastorius, a liquor store and a pancake house near the explosion site had windows blown out. A nearby hotel also had doors blown off and its portico was damaged, he told the Times.

“That was a very intense explosion,” Pastorius said.

The clinic is located near Desert Regional Medical Center, which did not sustain any serious damage.

"On Saturday morning, an explosion occurred at an unaffiliated office building across the street from Desert Regional Medical Center," according to a hospital statement. "Hospital staff is cooperating with police as they investigate the cause."

While the hospital's emergency department remains open, officials asked visitors to avoid the hospital if possible.

Gov. Gavin Newsom's office issued a statement saying Newsom "has been briefed on the explosion."

"The state, through the Office of Emergency Services, is coordinating with local and federal authorities to support the response," according to Newsom's office.

Assemblyman Greg Wallis, R-Rancho Mirage, posted on X, "I'm aware of the alarming explosion in Palm Springs and my heart goes out to all those affected. I'm working with law enforcement to understand this tragedy as it unfolds."

Rep. Ken Calvert, R-Palm Desert, also said his office was monitoring the situation.

This is a developing story. Check back for updates.