Access to healthcare in African countries continues to face the perennial hurdle of lack of well-equipped facilities coupled with high costs for medication. Despite these challenges, some milestones are being attained in scaling up investments. Smile Train, the world's largest cleft-focused organization, has been at the forefront of empowering local medical teams to provide safe and high-quality comprehensive cleft care to patients in their own communities. With 25 years of experience, Smile Train has been ensuring access and equity in healthcare, giving every child born with a cleft the opportunity to live a healthy and productive life. This model of partnership has been instrumental in bringing about positive change in the health sector across the continent. One significant milestone in this regard is the establishment of the first Africa National Cleft Care Centre in Ghana. Known as the Smile Train Cleft Leadership Centre, this facility is set to become a hub for training specialists and providing top-notch care to patients in need of cleft treatment. The collaboration between the Ghana Ministry of Health, the teaching hospital, the Ghana Cleft Foundation, and Smile Train highlights the importance of partnerships in advancing healthcare in Africa. This initiative not only benefits Ghana but also sets a precedent for the entire continent, emphasizing the critical role of partnerships in addressing healthcare gaps. The impact of such collaborations is evident in the improved access to care for patients with cleft conditions. By expanding capacity and enhancing access, organizations like Smile Train are contributing to the strengthening of health systems, ultimately leading to better patient outcomes. In a continent where the incidence of cleft births is significant, initiatives like the Smile Train Cleft Leadership Centre play a crucial role in providing specialized care and changing lives. The importance of leadership in achieving health outcomes cannot be overstated. In the context of shifting funding needs and evolving healthcare landscapes, effective leadership is essential for driving sustainable change. As Professor Peter Donkor highlights, having African leaders at the forefront of care is crucial, not only for representation but also for grooming future leaders in the field of surgical care. The strategic positioning of leaders within the healthcare sector is key to ensuring continued progress and positive health outcomes for the continent. Overall, the journey towards strengthening Africa's health sector is a collaborative effort that requires the active participation of governments, organizations, and healthcare professionals. Through sustained investments, strategic partnerships, and effective leadership, Africa's healthcare sector can overcome its challenges and pave the way for improved economic outcomes and a healthier population.