The series uses an animation style that's very much inspired by the Silver Age of comics, although it takes place in the modern day. There are also some aspects (Aunt May, generally having a more diverse cast) that harken more to the MCU, and especially the last scene is very much like one in one of the MCU live action movies, but with a twist. Also, Peter's best friend is Nico Minoru, whom you might know from another Marvel series; no clue yet as to whether she is like the comics or previous TV character with the same name.