However, Tottenham are faring better in the Europa League, sitting ninth in the table and still in the picture for automatic qualification to the last 16.
looks at who Ange Postecoglou could name in the Tottenham starting XI for the 5:45pm GMT kick-off at the Rhein-Neckar Arena.
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Pape Matar Sarr has been ruled out with a knock, joining a number of Tottenham players on the sidelines.
Guglielmo Vicario, Dominic Solanke, Destiny Udogie, Brennan Johnson, Timo Werner, Micky van de Ven and Wilson Odobert remain out.
Spurs have been boosted by the return to training of Cristian Romero, but this game will come too soon for the Argentine.
In addition, Antonin Kinsky, Djed Spence and Sergio Reguilon aren’t registered and so they cannot take part in the game.
Postecoglou faces a choice between Brandon Austin and Fraser Forster in goal, and we predict Austin will be given the nod in a bid to gain more experience.
The Tottenham boss suggested Archie Gray would play at left-back and Ben Davies would be at centre-back.
Radu Dragusin and Pedro Porro are expected to complete the back four, with Postecoglou not having much in the way of alternatives.
Rodrigo Bentancur is back in the squad after completing concussion protocols and is likely to come in at the base of midfield.
Meanwhile, Lucas Bergvall and James Maddison are pushing for further starts and could get the nod along with Bentancur.
Finally, the front line could be made up of Mikey Moore and Richarlison, both of whom did well off the bench against Everton, and Dejan Kulusevski.
This would see captain Son Heung-min earn a much-needed rest after he struggled against Everton.
Moore, who Gary Mabbutt backed to become a “superstar” in future, should once again get the chance to show what he can do.
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