Nine of a doctor's 10 children have been killed in an Israeli missile strike on their home in Gaza, which also left her surviving son badly injured and her husband in a critical condition.

Alaa Al Najjar, a paediatrician at Al Tahrir Clinic in the Nasser Medical Complex, was at work during the attack on her home, south of the city of Khan Younis in southern , on Friday.

Graphic footage shared by the Hamas-run Palestinian Civil Defence shows the bodies of at least seven small children being pulled from the rubble.

Rescuers can be seen battling fires and searching through a collapsed building, shouting out when they locate a body, before bringing the children out one by one and wrapping their remains in body bags.

In the footage, Dr Al Najjar's husband, Hamdi Al Najjar, who is also a doctor, is put on to a stretcher and then carried to an ambulance.

The oldest of their children was only 12 years old, according to Dr Muneer Alboursh, the director general of Gaza's health ministry, which is run by Hamas.

"This is the reality our medical staff in Gaza endure. Words fall short in describing the pain," he wrote in a social media post.

"In Gaza, it is not only healthcare workers who are targeted - Israel's aggression goes further, wiping out entire families."

Two British doctors working at Nasser Hospital described the attack as "horrific" and "unimaginable" for Dr Al Najjar.

Speaking in a video diary on Friday night, Dr Graeme Groom said his last patient of the day was Dr Al Najjar's 11-year-old son, who was badly injured and "seemed much younger as we lifted him on to the operating table".

The strike "may or may not have been aimed at his father", Dr Groom said, adding that the man had been left "very badly injured".

Dr Victoria Rose said the family "lived opposite a petrol station, so I don't know whether the bomb set off some massive fire".

Dr Groom added: "It is unimaginable for that poor woman, both of them are doctors here.

"The father was a physician at Nasser Hospital. He had no political and no military connections. He doesn't seem to be prominent on social media, and yet his poor wife is the only uninjured one, who has the prospect of losing her husband."

He said it was "a particularly sad day", while Dr Rose added: "That is life in Gaza. That is the way it goes in Gaza."

Sky News has approached the Israeli Defence Forces for comment.

Israel's war against Hamas in Gaza began when the militant group stormed across the border into Israel on 7 October 2023, killing some 1,200 people, most of them civilians, and abducting 251 others.

Israel's military response has flattened large areas of Gaza and killed more than 53,000 Palestinians, mostly women and children, according to Gaza's Hamas-run health ministry, which does not differentiate between civilians and combatants in its count.