Grey's Anatomy alum Patrick Dempsey has landed his next big role in a TV series.

Per TVLine, . The news was announced by the network during its Upfront presentation on Monday, where it was revealed that the show will premiere during the 2025-26 broadcast television season. Dempsey will be playing Angelo Ledda, a "hitman leading a dangerous double life, while hiding an even deadlier personal secret." That secret is that he develops early onset Alzheimer's, which adds new complications to balancing his two personas as a "fearsome NYC hitman and sleepy upstate Cooperstown photocopier salesman and father."

The official logline for Memory of a Killer reads, "Alzheimer’s is a foe he can’t outrun, and he knows too well how this ends, as his older brother is already lost to the condition. Angelo is exceptionally resourceful and talented, the best of the best. But he’s about to be tested like never before — and now every minute counts. This is only made more difficult when he discovers that his wife’s recent death may not have been an accident. So, when someone comes after his daughter — who is pregnant — it’s clear the wall between his lives has been breached. Angelo must stop whoever’s coming for his family by searching his past hits for clues, and the list is very long.”

“Now Angelo must hunt down his mortal enemy while continuing to carry out hits without giving away his diagnosis and still making it home in time to cook dinner for his daughter," the logline continues. "Memory of a Killer is a redemptive story about a man who is losing his memory but gaining a conscience. Because Angelo knows he must stop history from repeating itself and save his family — before he forgets the past.”

The series comes from Ed Whitmore and Tracey Malone. The two are serving as executive producers alongside Cathy Schulma, Arthur Sarkissian, Martin Campbell, and Peter Bouckaert. No other cast members have yet been named.

Dempsey, who's best known for his run on Grey's Anatomy, recently appeared in the Dexter prequel series, Dexter: Original Sin. He also starred in the triller series Devils. There were reports that Dempsey was eyed to return to the Scream franchise in the upcoming sequel, Scream 7, after he'd previously appeared in the third film of the movie series. That casting ultimately did not work out.

"It just didn’t work out and we were dealing with the [L.A.] fires and everything that was going on and the schedule didn’t work out, unfortunately," Dempsey told Variety.

Source: TVLine