The list of causative agents that laboratories must notify the UK Health Security Agency (UKHSA) about has been expanded to include additional  notifiable organisms which became reportable under the Health Protection (Notification) (Amendment) Regulations from 6 April 2025. Publication of the additional causative agents will begin at a later date, once reporting development work has been undertaken to include them.

Laboratories in England have a statutory duty to notify the UK Health Security Agency (UKHSA) of the identification of the following causative agents:

Totals for the current week compared to the previous 5.

Week notification received	2025/15	2025/16	2025/17	2025/18	2025/19	2025/20
Arboviruses
West Nile Virus	-	-	1	-	-	-
Bacillus
Bacillus cereus	27	33	18	21	28	28
Bordetella
Bordetella pertussis	8	8	4	13	7	5
Borrelia
Borrelia burgdorferi	13	17	17	12	16	34
Borrelia sp	1	2	4	2	4	1
Brucella
Brucella melitensis	1	-	-	-	-	-
Brucella sp	1	1	3	1	-	1
Campylobacter
Campylobacter coli	34	21	19	30	31	31
Campylobacter fetus	1	-	-	1	1	2
Campylobacter gracilis	-	1	-	-	-	-
Campylobacter hyointestinalis	-	-	-	-	1	-
Campylobacter jejuni	303	293	244	342	271	312
Campylobacter lari	1	-	-	-	-	-
Campylobacter other named	3	4	1	-	3	-
Campylobacter rectus	-	-	-	1	-	-
Campylobacter sp	988	1,046	880	1,117	887	1,257
Campylobacter upsaliensis	-	1	-	-	-	3
Campylobacter ureolyticus (bacteroides corrodens)	2	1	-	1	1	1
Chikungunya virus
Chikungunya virus	-	-	-	1	2	-
Clostridium
Clostridium perfringens	37	37	46	35	41	36
Coronavirus
Coronavirus	114	99	87	67	57	50
Human coronavirus 229e	4	2	3	1	-	1
SARS-CoV-2 antibody void	6	20	26	20	14	12
SARS-CoV-2 coronavirus (COVID-19)	1,277	1,199	1,229	1,214	955	1,120
SARS-CoV-2 coronavirus (COVID-19) indeterminate	44	30	65	48	63	51
SARS-CoV-2 IgG antibody negative	12	24	32	21	15	11
SARS-CoV-2 IgG antibody positive	62	47	86	117	77	71
SARS-CoV-2 total antibody negative	4	4	4	8	8	-
SARS-CoV-2 total antibody positive	16	18	20	44	13	22
Corynebacterium
Corynebacterium diphtheriae	1	1	3	2	3	4
Corynebacterium ulcerans	-	-	-	1	1	-
Coxiella
Coxiella burnetii	-	1	-	1	-	1
Cryptosporidium
Cryptosporidium hominis	4	3	3	13	9	4
Cryptosporidium parvum	43	39	64	96	68	44
Cryptosporidium sp	36	26	46	81	41	104
Cryptosporidium ubiquitum	-	-	-	-	1	-
Entamoeba
Entamoeba histolytica	1	4	4	3	5	7
Escherichia
Escherichia coli O 157	11	6	11	10	5	8
Flaviviruses
Dengue virus	2	4	2	11	5	2
Giardia
Giardia sp	91	117	93	119	78	148
Haemophilus
Haemophilus influenzae	91	58	65	78	63	74
Hepatitis viruses
Hepatitis A	29	19	19	13	17	17
Hepatitis B	304	299	309	275	250	285
Hepatitis C	291	261	267	292	211	314
Hepatitis D	3	5	3	7	6	3
Hepatitis E	34	32	36	35	39	43
Influenza virus
Influenza A	911	710	647	497	350	311
Influenza B	687	432	308	189	104	71
Influenza indeterminate	-	-	8	-	-	4
Influenza ungrouped	28	31	28	17	5	10
Legionella
Legionella longbeachae	-	-	-	-	-	1
Legionella pneumophila	7	1	7	2	6	9
Legionella sp	4	2	5	1	2	6
Leptospira
Leptospira interrogans	-	1	-	-	-	-
Listeria
Listeria monocytogenes	13	2	2	4	3	6
Mycobacterium
Mycobacterium tuberculosis	110	108	88	97	67	80
Neisseria
Neisseria meningitidis	35	36	23	29	24	26
Orthopoxvirus
Mpox virus positive	5	5	5	13	8	7
Paramyxoviruses
Measles virus	14	19	20	12	28	27
Mumps virus	15	10	3	3	9	8
Plasmodium
Plasmodium falciparum	4	2	-	-	-	11
Plasmodium malariae	1	-	-	-	-	1
Plasmodium ovale	2	1	-	-	-	1
Plasmodium vivax	-	-	-	-	-	1
Polyomavirus
Polyomavirus BK	63	57	46	46	42	50
Polyomavirus JC	9	12	8	6	10	13
Polyomavirus untyped	6	8	8	26	9	15
Rickettsia
Rickettsia prowazekii	-	-	1	-	-	-
Rickettsia tsutsugamushi	-	-	-	1	-	-
Rubella virus
Rubella virus	1	3	-	5	3	1
Salmonella
Other salmonellas	61	73	66	66	30	25
Salmonella agona	-	-	7	-	-	-
Salmonella enteritidis	21	36	47	61	27	12
Salmonella infantis	-	-	5	-	-	-
Salmonella java	5	-	-	5	-	-
Salmonella kottbus	-	5	-	-	-	-
Salmonella newport	5	5	-	7	-	-
Salmonella saint-paul	-	-	5	7	-	-
Salmonella sp	14	36	18	50	94	159
Salmonella stanley	-	-	-	6	-	-
Salmonella typhi and paratyphi	15	11	14	27	16	14
Salmonella typhimurium	17	16	23	17	18	10
Slmonella enterica	-	-	-	6	-	-
Shigella
Shigella boydii	2	1	1	3	-	-
Shigella dysenteriae	1	-	1	3	-	-
Shigella flexneri	15	31	15	18	18	10
Shigella sonnei	16	13	14	22	16	8
Shigella sp	34	55	45	81	64	93
Streptococcus
Streptococcus group A	54	62	49	59	52	65
Streptococcus pneumoniae	151	169	163	127	95	127
Vibrio
Vibrio cholerae	-	2	1	1	2	2

For all Carbapenemase-producing Gram-negative organisms, the reports are de-duplicated by first mention of organism species and resistance mechanism by person in a rolling 52-week period.

Note: the numbers presented here do not include specimens that have been referred to the AMRHAI Reference Unit.

Week notification received		2025/15	2025/16	2025/17	2025/18	2025/19	2025/20
Citrobacter
Citrobacter spp	IMP	-	-	-	-	1	-
	KPC	1	2	-	-	-	-
	NDM	-	-	1	-	2	-
	OXA48	4	5	2	2	1	1
Enterobacter
Enterobacter cloacae complex	IMP	4	4	1	1	3	1
	KPC	5	4	5	5	5	1
	NDM	7	5	3	4	8	2
	OXA48	6	4	4	5	4	-
	VIM	-	-	-	-	-	1
	Other	1	1	1	2	1	-
Other enterobacter spp	NDM	-	-	-	1	-	-
	OXA48	-	-	-	1	-	-
Escherichia
Escherichia coli	KPC	-	3	-	1	5	1
	NDM	18	19	19	21	22	1
	OXA48	20	28	19	22	16	2
	VIM	-	-	-	-	1	1
	Other	3	3	1	1	-	1
Hafnia
Hafnia alvei	KPC	-	-	-	-	1	-
Klebsiella
Klebsiella aerogenes	IMP	1	-	-	-	-	-
	OXA48	-	-	-	-	-	1
Klebsiella oxytoca	KPC	1	-	-	2	-	-
	NDM	-	-	-	1	-	-
	OXA48	1	2	1	-	2	-
Klebsiella pneumoniae	IMP	2	2	1	1	1	-
	KPC	7	6	6	4	3	1
	NDM	6	11	11	14	11	3
	OXA48	10	17	9	14	16	2
	VIM	-	1	-	-	-	-
	Other	2	1	2	4	1	4
Klebsiella variicola	KPC	-	-	-	-	-	1
Morganella
Morganella morganii	OXA48	1	-	-	-	-	-
Proteus
Proteus mirabilis	NDM	3	-	2	1	2	1
	Other	2	1	1	2	1	-
Other proteus spp	NDM	-	-	-	2	-	-
Raoultella
Raoultella ornithinolytica	KPC	1	-	-	-	-	-
Other raoultella spp	KPC	-	-	1	-	-	-
	VIM	-	-	1	-	-	-
Serratia
Serratia marcescens/ureilytica	NDM	-	-	-	-	1	-

For all Carbapenemase-producing Gram-negative organisms, the reports are de-duplicated by first mention of organism species and resistance mechanism by person in a rolling 52-week period.

Note: the numbers presented here do not include specimens that have been referred to.

Week notification received		2025/15	2025/16	2025/17	2025/18	2025/19	2025/20
Acinetobacter
Acinetobacter baumannii	NDM	1	-	-	-	-	-
Pseudomonas
Pseudomonas aeruginosa	NDM	-	1	-	-	-	-
	VIM	1	-	-	-	1	-
	Other	1	4	1	1	1	-
Pseudomonas fluorescens group	VIM	-	1	-	-	-	-
Pseudomonas putida group	VIM	-	-	-	1	-	-
Other
	NDM	-	1	-	-	-	-
	OXA48	-	1	-	-	1	1